Y: The Last Man (2002), Volume 4

After a devastating plague, Yorick Brown is the last man left alive in a world of women. On the run from Amazon extremists who would be happy to see him dead, his friends leave him in the care of Agent 711. But 711is not the tragic woman she seems to be and Yorick is propelled into a drug-fueled nightmare of blood and sadism. Collects issues #18-23 of the runaway hit Vertigo series by Brian K. Vaughan (EX-MACHINA, RUNAWAYS) and Pia Guerra.